5 stars (25)
- Aloft By Marriott Panama Hotel
- American Trade Hotel Panama City
- Bristol Panama, A Registry Collection Hotel
- Central Hotel Panama
- Decapolis Hotel Panama City
- Dreams Playa Bonita All Inclusive Panama City
- Global Hotel Panama
- Gran Evenia Panama Hotel
- Hotel El Panama By Faranda Grand, A Member Of Radisson Individuals
- Hotel La Compania Casco Antiguo Panama City
- Hotel Las Americas Golden Tower Panama
- Hyatt Regency Panama City
- Intercontinental Miramar Panama By Ihg Hotel
- Jw Marriott Panama Hotel
- Le Meridien Panama
- Megapolis Hotel Panama
- Radisson Hotel Panama Canal
- Renaissance Panama City Hotel
- Riu Plaza Panama Hotel
- Sheraton Grand Panama
- Sofitel Legend Casco Viejo, Panama City
- The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
- The Westin Panama Hotel
- W Panama Hotel
- Waldorf Astoria Panama Hotel
4 stars (20)
- Ac Hotel By Marriott Panama City
- Best Western Plus Panama Zen Hotel
- Crowne Plaza Panama By Ihg Hotel
- Hilton Garden Inn Panama City Downtown, Panama
- Hilton Panama Hotel
- Holiday Inn Panama Canal By Ihg
- Hotel Coral Suites Panama City
- Hotel Magnolia Boutique
- La Concordia Boutique Hotel Panama City
- Marinn Place Financial District Panama City
- Marriott Executive Apartments Panama City, Finisterre
- Marriott Panama Hotel - Albrook
- Novotel Panama City
- Paitilla Panama Apartments
- Residence Inn By Marriott Panama City
- Riande Urban Hotel Panama City
- Summit Rainforest Golf Resort & All Inclusive Panama City
- Tantalo Hotel - Kitchen - Roofbar Panama City
- The Executive Hotel Panama City
- Tryp By Wyndham Panama Centro Hotel
3 stars (6)
- Hampton By Hilton Panama Hotel
- Hotel Centroamericano Panama City
- Hotel Marbella Panama City
- Hotel Terranova Panama City
- The Beach House Panama City
- Viajero Casco Viejo Hostel Panama City